Noncoding RNAs (ncRNAs), especially microRNA (miRNA) and long noncoding RNA (lncRNA), have an impact on a variety of\nimportant biological processes during colon adenocarcinoma (COAD) progression. This includes chromatin organization,\ntranscriptional and posttranscriptional regulation, and cell-cell signaling. The aim of this study is to identify the ncRNAregulated\nmodules that accompany the progression of COAD and to analyze their mechanisms, in order to screen the potential\nprognostic biomarkers for COAD. An integrative molecular analysis was carried out to identify the crosstalks of gene modules\nbetween different COAD stages, as well as the essential ncRNAs in the posttranscriptional regulation of these modules. 31\nncRNA regulatory modules were found to be significantly associated with overall survival in COAD patients. 17 out of the 31\nmodules (in which ncRNAs played essential roles) had improved the predictive ability for COAD patient survival compared to\nonly the mRNAs of those modules, which were enriched in the core cancer hallmark pathways with closer interactions. These\nsuggest that the ncRNAsâ?? regulatory modules not only exhibit close relation to COAD progression but also reflect the dynamic\nsignificant crosstalk of genes in the modules to the different malignant extent of COAD.
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